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An elderly Jesuit priest named Father Lankester Merrin is leading an archaeological dig in northern Iraq and studying ancient relics. Following the discovery of a small statue of the demon Pazuzu (an actual ancient Sumerian demigod) and a modern-day St. Joseph medal curiously juxtaposed together at the site, a series of omens alerts him to a pending confrontation with a powerful evil, which unknown to the reader at this point, he has battled before in an exorcism in Africa. Meanwhile, in Georgetown, a young girl named Regan MacNeil living with her famous actress mother, Chris, becomes inexplicably ill. After a gradual series of poltergeist-like disturbances, she undergoes disturbing psychological and physical changes, appearing to become "possessed" by a demonic spirit.
After several unsuccessful psychiatric and medical treatments, Regan's mother turns to a local Jesuit priest. ...