She currently appears in the AMC original television drama series Mad Men as young suburban housewife and mother Betty Draper. She is also well known for her role as Cadence Flaherty in American Wedding (2003), from the American Pie comedy film series.
She had the lead female role in the movie Love's Enduring Promise as a pioneer family's oldest child. Her character fell in love with a mysterious man who saved her father's life.
Jones has had supporting roles in Anger Management (2003), Love Actually, and Dirty Dancing: Havana Nights. In 2005 she appeared as a U.S. border guard's frustrated wife in the film The Three Burials of Melquiades Estrada directed by and starring Tommy Lee Jones. In We Are Marshall (2006), she played the role of Carol Dawson, wife of football coach William "Red" Dawson.
She appeared in the Season 18 Law & Order episode "Quit Claim", playing a slippery, manipulative con artist who matches wits with Assistant District Attorney Cutter, in which she is the lone surviving suspect connected to a real estate scam involving organized crime.
She also appeared in The Boat That Rocked released in 2009.