Middlesex is a novel by Jeffrey Eugenides. It was published in 2002 and won the Pulitzer Prize for Fiction in 2003.
The narrator and protagonist, Calliope Stephanides (later called "Cal"), an intersexed person of Greek descent, has 5-alpha-reductase deficiency. The bulk of the novel is devoted to telling his coming-of-age story growing up in Detroit, Michigan in the late 20th century. This story, however, is intertwined with elements of a family saga, meditations on the era's zeitgeist and bits of contemporary history.
The novel begins with the narrator, aged 41, deciding to tell the story of his recessive gene that caused him to be born Calliope and later to become Cal. The narration periodically returns to the frame story of present-day Cal, who is bearded, male and interested in women, foreshadowing the personal revelations of Callie.