Lewis Black takes on a lot of issues from the current political scene, to a troubled kid growing up. This book is really an autobiography that takes different parts of Black's life and summarizes each part into a specific theme, with Black's keen insight and a lot of humor thrown in.
Black seemed to be someone from highly intelligent parents (his father built ocean mines and his mother was a math teacher) who probably got involved with the wrong crowd and got caught in the drug craze of the 60's and 70's. Somehow he never let himself fall too far and was able to straighten himself out on his own (he never mentions in the book if he ever went through rehab). He seemed to have a lot of talents that never panned out and was lucky to get a break with his comedy.
Black seems to have a pretty keen prospective of the goings on in Washington. Though he really attacks the current administration and is obviously a democrat, it doesn't stop him from attacking every president that followed Kennedy whether they were democrat or republican. There is an incident described by Black involving Johnson and the corpse of Kennedy that may turn readers off (Black lets you know in advance in case you want to skip over those pages) and you are not sure if he was being serious or not.