Comic book about the travels of a group of people trying to …

The story primarily concerns the difficult relationship between two women, Helen Francine Peters (known simply as Francine) and Katina Marie ("Katchoo") Choovanski, and their friends David Qin and Gwynnethina Casey Bullocks-Femur (known as Casey). Francine considers Katchoo her best friend; Katchoo is in love with Francine. David is in love with Katchoo (a relationship which Katchoo herself is deeply confused about) and Casey is in love with David.
This plays itself out over a second plot element, a thriller style story concerning the shadowy 'Big Six' organization. Its leader is a woman named Darcy Parker, who uses highly trained women (of whom Katchoo was one) to infiltrate—and to an extent control—the American political system. It uses a non-linear approach to storytelling, putting in sequence elements of the story often years apart, and going back in time frequently.