The 2010 World Series will be the 106th edition of Major League Baseball's championship series. The best-of-seven playoff will be played between the American League champion Texas Rangers and the National League champion San Francisco Giants, and is set to begin on Wednesday, October 27. Unless the series is a sweep and there are no weather delays, the series will go into November for the second year in a row, but just the third time ever. The latest possible ending of the series is scheduled for November 4, barring weather delays. In their respective league championship series, the Rangers and Giants eliminated the 2009 World Series teams, the New York Yankees and the Philadelphia Phillies, to advance.

The Rangers' advancement marks the first time that the franchise has appeared in the World Series in its 50-year history, dating back to the club's days as the Washington Senators. The Giants' victory over the Phillies gave them their fourth World Series appearance ever since relocating to San Francisco before the 1958 season; their most recent appearance was in the 2002 World Series, when they lost to the Anaheim Angels in seven games.

The Giants will have home field advantage in the World Series, the first time the National League champion has had home field advantage since 2001, as the NL won the All-Star Game 3–1 on July 13.

For the second consecutive year, Series games will have earlier start times in hopes of attracting younger viewers. First pitch will be at 7:57PM EDT for most games. Game 3 will start at 6:57PM EDT. Game 4 will start at 8:20PM EDT to accommodate Fox's football coverage.