"Grillz" is a 2005 rap single from the album Sweatsuit by Nelly featuring Paul Wall and Ali & Gipp (a duo composed of Ali from the St. Lunatics and Big Gipp from the Goodie Mob) about grills, cosmetic dental apparatuses. Brandi Williams is featured on the single "Grillz" but is uncredited. There is a remix featuring Chingo Bling on the album Dollarado 2 Texas. Another official remix is West Coast remix and it features Diamonique and Lil' Rob. In six weeks, Grillz reached the top five of the Billboard Hot 100, and number one in its tenth week (in 2006), becoming Nelly's fourth number one hit. It also became #1 on the Hot Ringtones chart.In the UK, it became his least successful single since"Iz U" charting at only #24. "Grillz" samples "Soldier" by Destiny's Child, a No. 3 Hot 100 hit for the group.

"Grillz" was able to top the Billboard Hot 100 on its tenth week giving Nelly his 4th number 1 in the US. It was not as successful in the UK though reaching number 24 which was his least successful single since "Iz U" in 2003.