Mae Hong Son can be reached by car or bus from Chiang Mai by the Mae Hong Son loop. The town is also serviced by the Mae Hong Son Airport. The town has some tourist infrastructure, including many guesthouses and several internet cafes. It also has a vegetarian restaurant near the main market.
It is a popular jumping-off point for tours to visit hill tribe villages, caves, and waterfalls in the area. There are also some hot springs nearby. "Thung Dok Bua Tong" in Amphoe Khun Yuam, where the fields of wild sunflowers bloom and cover the hills during the month of November, is best reached from Mae Hong Son and lies some 80 km away.