Cat in the Brain has been compared to the horror film equivalent of Federico Fellini's classic self-reflective "film about making films", 8 1/2, using cynical, grand guignol humour. Juxtaposing gory horror clips from several of his own past horror films which he either directed and/or produced, Lucio Fulci cleverly shot a wrap-around segment featuring his own plot and used Vincenzo Tomassi's film editing (as well as his own voice over) to create the fresh storyline - a witty and darkly humorous personal insight into the effects of horror filmmaking on the psyche.
Cat in the Brain is a tongue-in-cheek horror "meta" film, examining a filmmakers own self-reflexive filmmaking as well as the larger social and psychological effects of movie violence. According to one reviewer, "You have chainsaws, severed limbs hacked off by different types of weapons, hammer smashed faces (I think that is a Cannibal Corpse tune), decapitations, melting heads in microwaves, lots of female battery, nazis, strangulation, and more." In other words, a typical Italian "giallo" horror film with all its exploitative elements sprinkled in like Parmesan cheese on top of a bloody spaghetti of found footage.