Osmosis Jones is one of those movies you almost feel like you have to apologize for liking. Well, forget about it, because this is a very funny and downright entertaining movie with no class whatsoever!
The scenes bounce between live acting and full animation, determined by whether we are outside or inside the body of Frank. The casting for this silly and peculiar movie was expertly chosen for both live and voice roles.
Live, we have Bill Murray as Frank, in his most disgusting character since Caddyshack. Chris Elliot plays his brother Bob, and manages to challenge Murray in the "disgusting slob" category. Murray eats a hard boiled egg that landed in monkey doodoo, and thus introduces Thrax into his body, a red-death virus determined to take over Frank and kill him. (voiced by Laurence Fishburne)
Inside of Frank, we go to the animation where Chris Rock is the voice of our hero, a white blood cell named Osmosis Jones. Jones is a detective for the City Of Frank, where William Shatner does the voice for Mayor Phlemming. Jones knows something is wrong, but the Mayor denies any illness could occur in Frank. But just to be safe, he "manually overrides" Frank and has him take a cold pill.
Meet Drix, the huge and snotty cold pill, whose voice is played by David Hyde Pierce (Frazier's brother Niles). Jones and Drix make an unlikely team as they hunt down Thrax and try to stop him from killing Frank.
Nothing is taboo here; they go to the nose and get caught up in the wave of snot when Frank's allergies act up, they travel to The Zit, Frank's hottest new club where Kidney Rock is playing (Kidd Rock), and Jones reminisces about the time he hit the "Panic Button" in Frank's stomach, causing him to vomit all over his daughter Shane's teacher. (played live action by Molly Shannon)
Boogers, snot, vomit, farts, and zits; its all here. Ron Howard even does a guest voice as Tom Colonic, running for Mayor against Phlemming, who broadcasts his campaign commercial from The Bowels.
This is visceral entertainment with a squishy feel to it, riotously funny and well endowed with toilet humor; silly campy comedy at its very best. In David Litton's excellent review below, he mentioned that this was a "Fun Time-waster". Indeed it is, David. Enjoy!