First let me say, to look for somekind of high-budget masterpiece here is like climbing a tree in search of a fish!
This is a made for tv movie and it is a b-movie/(small-budget).
For what it is Anacondas: Trail of Blood is not bad.
The story takes place in the Carpathian Mountains of Eastern Europe, some rich guy wants to live long and overcome his physical condition so he invests lots of money in some kind of private out of the way pharmaceutical lab to extract from an orchid plant a promising new drug. The lab experiments with snakes and a side effect is a very big hungry snake that breaks loose in the local surrounding woods eating people! Scientist lady and team go out to find it and destroy it.
Yeah, that's it folks - Anacondas: Trail of Blood dosen't pretend to be some important movie that's going to set a new standard for the movie world or change the world. And that's exactly why i liked it. I get tired of self-important big "showcase" movies. Now the story does carry a sort of message like; 'don't mess with nature' - a Frankenstein kind of thing but without preaching about it.
Bottom line; I found this movie to be scary good fun. Just don't get to hung-up on how good or bad the CGI is, and you might very well enjoy it. The people and relationships in it are interesting; especially that of Amanda's platonic love for Alex and the more romantic love of Jackson & Heather and the age difference between these adults. (I'm guessing Amanda is in her early 30s and Alex is about 21/Jackson 40 and Heather 25?). Both of these relationships are portrayed in a meaningful way - as mentioned before, for what it is, a giant snake movie.
Anacondas: The Hunt for the Blood Orchid is also good.