NCIS (Naval Criminal Investigative Service) is an action drama focusing on the complexity and humor that comes with working together as a team in stressful situations.

Leading the troupe is NCIS Special Agent Leroy Jethro Gibbs (Mark Harmon), a former Marine gunnery sergeant, turned investigator. Rounding out the team is the new NCIS director, Leon Vance (Rocky Carroll) who constantly challenges Gibbs with his no-nonsense attitude. The rest of the team is composed of NCIS Special Agent Anthony DiNozzo (Michael Weatherly), an ex-homicide detective  with unparalleled instincts in the field, Abby Sciuto (Pauley Perrette)), a talented scientist whose dark wit matches her Goth style and eclectic tastes, NCIS Special Agent Timothy McGee (Sean Murray), a brilliant MIT graduate and agent Ziva David (Cote de Pablo). Dr. Donald "Ducky" Mallard (David McCallum) assists the team as medical examiner who knows it all.

The agents travel the globe battling murder, espionage, terrorism and all crimes associated with the Navy or Marine Corps.