Perhaps you've found a young lady dressed as Xena who has caught your attention? Maybe that guy dressed as Thor is giving you saucy looks? What are you going to say to David Tennant when you finally get to meet him after waiting hours in line?
Be prepared! Have plenty of opening lines at your disposal when attending conventions. If you go to conventions hoping to find love, make sure that your opening line won't drive people away. Notice what your selected target is wearing. Compliment their makeup if they are in costume. Ask them if they've seen the latest episode of "Being Human." Comment on their Jayne hat. Pretty much anything along these lines will help you initialize conversation.
As for myself (being married and, as such, pretty much out of the running for finding love at a convention), the most important opening lines I worry about are those I say to the celebrities I meet. If you're lucky, you'll run into a very talkative and friendly celeb like Chase Masterson or Daniel Logan who will start up the conversation without you ever having to say a word. Other celebs, however, say hello to you and then wait for your first question.
A little research can go a long way in the celebrity department. Ask around the convention to see which celebs are talkative and which ones stay fairly quiet. A lot of convention attendees have met many of the visiting celebs on a number of occasions and can offer up great advice about how to approach them. Some celebs do not like people bringing up certain bad movies from their past, while others love it when fans mention how they share a love for a particular social cause, pet, etc.
Here's a freebie tip: Challenge Richard Hatch to a thumb war!
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