What did you think of this review?
5-Hydroxytryptophan (5-HTP), also known as oxitriptan
(INN), is a naturally-occurring amino acid and chemical
precursor as well as metabolic intermediate in the
biosynthesis of the neurotransmitters serotonin and
melatonin from tryptophan.
5-HTP is sold over-the-counter in the United States and
Canada as a dietary supplement for use as an
antidepressant, appetite suppressant, and sleep aid,
and is also marketed in many European countries for the
indication of major depression under trade names
like Cincofarm, Levothym, Levotonine,Oxyfan,
Telesol, Tript-OH, and Triptum. Several
double-blind placebo-controlled clinical trials have
demonstrated the effectiveness of 5-HTP in the
treatment of depression, though a lack of high
quality studies has been noted.
Because 5-HTP has not been thoroughly studied in
a clinical setting, possible side effects and interactions
with other drugs are not well known.
Administered serotonin has been shown to increase
the risk of heart valve disease in animals. 5-HTP
has not been subjected to this test. Oral 5-HTP results
in an ...