Doug and Carrie Heffernan (Kevin James and Leah Remini) share their home in Rego Park, Queens, New York City with Carrie's oddball dad, Arthur Spooner (Jerry Stiller).
Doug, who makes a living as a delivery person for the International Parcel Service (IPS), spends most of his time at his home with wife Carrie. Carrie works as a secretary for a law firm in midtown Manhattan. This is complicated by Arthur, who can be quite a handful — so much so that they hired a dog walker, Holly (Nicole Sullivan), to look after him by walking him, with the dogs, in the local park.
Doug hangs with his advice-giving buddies Deacon Palmer (Victor Williams), Spence Olchin (Patton Oswalt), Richie Iannucci (Larry Romano) and his cousin Danny Heffernan (Gary Valentine). His friend Spence is a Star Trek-loving geek who isn't very savvy when it comes to women. Deacon Palmer is Doug's best friend, and can often be seen going to Knicks' games with Doug or just hanging out with Spence, Richie, and Danny.