In one of the funniest guest appearances on the show, George Takei teamed up with Katee Sackhoff to give Howard love advice with his girlfriend, Bernadette, in The Hot Troll Deviation. The dynamic duo argued over who knew what a woman really wants, with Sackhoff eventually winning the argument.
Of course, if you didn't know that Takei is best known as Sulu from the Star Trek universe, you've been living under a rock for a very long time. Takei has made guest appearances on many programs over the years, often poking fun at his Sulu past. He has also been a strong gay rights advocate over the years, and has popularized the phrase, "It's okay to be Takei," a response he made to the Tennessee State Legislature's "Don't Say Gay" bill.
Despite having received numerous awards for his work in astrophysics, being a guest on multiple programs on radio and television, and hosting a series on PBS, Dr. Neil deGrasse Tyson received nothing but ill words from Sheldon after being introduced to him by Raj. Sheldon was unhappy that Tyson's work caused Pluto to lose its status as a planet.
Tyson is no stranger to television. He is often a guest or host of programs that air on PBS, the History Channel, and other networks. He also has appeared on many comedic talk shows such as The Colbert Report.
Of all of the scientists on this list, Tyson is probably the most visible as far as media appearances are concerned.
Howard Wolowitz is no stranger to fantasies, whether they be the kind that involve sword and sorcery or topics of a more adult nature. Unfortunately for Katee Sackhoff (of Battlestar Galactica fame), she is often the subject of some of Howard's more risque fantasies. She has appeared in two episodes of The Big Bang Theory as part of Howard's fantasy world. Luckily for her, though, she had the upper hand in both appearances.
In one episode, she finds herself in a bubble bath with Howard and gives him some tough and sarcastic advice on committing to Bernadette. In her second appearance, she teams up with George Takei as they attempt to help Howard rekindle his romance with Bernadette.
Sackhoff and Takei make a great team, and her completely uncaring attitude toward Howard (although she really does help him in the long run) is hilarious to watch on the screen.
While it doesn't take much to get added to Sheldon's Mortal Enemy List, Brent Spiner goes above and beyond in order to do so. Wil Wheaton, Sheldon's mortal enemy, gives him an autographed Wesley Crusher figure as an apologetic act for Wheaton's past actions. For this, Sheldon gives him a hug and removes him from his list. Brent Spiner, another Star Trek: The Next Generation alum, then takes the figure and opens the box it is in, ruining its value. Sheldon immediately puts the former "Data" at the top of his list.
Spiner has made numerous guest appearances over the years, and has also released many albums as well. I'm glad to see that he has become Sheldon's mortal enemy, and something tells me that Spiner and Wheaton have a big scheme going behind Sheldon's back in order to create even more chaos in his world.
Regular readers of my lists and reviews might know that I'm a huge fan of LeVar Burton and his work on Star Trek: The Next Generation, but I really love him for his time on Reading Rainbow, which inspired me to explore the wonderful world of books. Needless to say, when he is mentioned as a potential "friend" of Sheldon (he invited him to a party via Twitter), I was ecstatic.
As the episode, "The Toast Derivation," rolled along, however, I thought that Burton would be a no-show. Finally my patience paid off when Burton briefly appeared in the final minutes of the show, where he walks in on Kripke, Zack, and a naked Stuart (covered only in a towel) singing karaoke. He immediately shuts the door and utters the funny line, "I am so done with Twitter."
What did you think of this list?